Abstract
The injection of pilocarpine nitrate in mice in doses of 0.5 mg per gram of total body weight causes a marked fall in the activity of alkaline phosphatase in the cholinergic sweat glands of the foot-pads and in the duodenal mucosa. The decrease in activity is maximal about 1 hour after injection and reverts to normal levels in 4 hours in the duodenum, and in about 24 hours in the sweat glands. This is demonstrated both histochemically in sections and chemically in homogenates of whole tissue. No changes in alkaline phosphatase activity in the non-cholinergic kidney cortex are seen following the injection. It is shown that this effect is not due to a direct inhibitory effect of pilocarpine on alkaline phosphatase. Possible mechanisms of the observed effects are discussed.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
