Abstract
Transitions in nanostructure driven by pH are observed for a self-assembling peptide amphiphile (PA) with a cationic pentapeptide headgroup. At pH 3, the PA forms flat tape-like structures, while at pH 4 the PA assembles into twisted right handed structures. These twisted structures transform again to flat tape-like structures at pH 7. In complete contrast, spherical micelles are observed at pH 2. These changes in response to pH may be relevant to biological and pharmaceutical applications of this PA in skincare.
Highlights
Transitions in nanostructure driven by pH are observed for a selfassembling peptide amphiphile (PA) with a cationic pentapeptide headgroup
Peptide amphiphiles (PAs) are remarkable molecules in which the biofunctionality of peptides is controlled by the amphiphilicity imparted by attachment of lipid chains
We investigate the in uence of pH on the self-assembly of the PA C16-KTTKS which has a pentapeptide headgroup based on a sequence from pro-collagen I
Summary
Transitions in nanostructure driven by pH are observed for a selfassembling peptide amphiphile (PA) with a cationic pentapeptide headgroup. We investigate the in uence of pH on the self-assembly of the PA C16-KTTKS which has a pentapeptide headgroup based on a sequence from pro-collagen I.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
