Abstract
The aim of the present study is for evaluating the effect of different doses of palmitic acid on spatial learning in T-maze. So, Wister adult male rats were used in five groups and considered 10 rats for each group. The first group as a control group was fed with ordinary diet. Four groups were fed with a diet containing palmitic acid (10%) for 1, 2, 3 and 4 weeks, then rats were trained for spatial learning task by using T-maze at subsequently 9 days based on standard method. The result showed that, spatial learning increased by diet containing palmitic acid 10% for 1, 2 and 3 weeks were significant (p<0.05). However, dietary palmitic acid effect on learning because palmitic acid via palmitoylation modifies numerous important neuronal protein including GAP-43, NMDA receptor, AMPA receptor and these receptors are critical role in learning.
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