Abstract
Summary Short term treatment (10 days) of rats with oxytetracycline and doxycycline, leads to a decreased level of γ-carboxyglutamate in femoral bone and in kidney cortex. The decrease is more pronounced with oxytetracycline than with doxycycline. Slight effect was exerted also by fusidic acid and lincomycin; cloxacyllin was not affecting the γ-carboxyglutamate level in either tissue. The drop in γ-carboxyglutamate concentration paralelled the decrease in bone calcium (Ca++/Hyp concentration). No evidence is available at present indicating any blocking effect of either oxytetracycline or doxycycline on posttranslational γ-carboxylation of glutamic acid; γ-carboxyglutamic acid containing protein with normal proportion of γ-carboxyglutamate (70 residues per 1000 residues) was isolated from femoral bones of oxytetracycline treated rats, however its recovery was much lower than in control rats.
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