Abstract
AbstractThe effect of non‐competitive (MK‐801:/+/‐5‐methy‐10,11‐dihydro‐5H‐dibenzo [a, d] cyclohepten‐5,10‐imine hydrogen maleate) and competitive (CGP 37849: DL‐/E/‐2‐amino‐4‐methyl‐5‐phosphono‐3‐pentenoic acid) NMDA receptor antagonists on the catalepsy induced by neuroleptics in mice was studied. MK‐801 and CGP 37849 antagonized the catalepsy induced by haloperidol, spiperone and fluphenazine. (+)‐Cycloserine, a partial glycine agonist, reversed the anticataleptic effect of CGP 37849, but not that of MK‐801. The above results indicate that the anticataleptic activity of both these NMDA receptor antagonists is induced by an indirect activation of the dopamine system. The results provide further evidence that competitive NMDA receptor antagonists may be a new class of antiparkinsonian drugs.
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