Abstract
Objective To investigate the curative effect of naloxone combined with branched-chain amino acids and ornithine aspartate on hepatic encephalopathy (HE). Methods One hundred and six patients with HE were randomly divided into two groups:treatment group and control group.Both groups were given conventional treatment measures,patients in treatment group(54 cases) were added naloxone combined with branched-chain amino acids and ornithine aspartate,patients in control group(52 cases) were added branched-chain amino acids and ornithine aspartate. The two groups were compared with average awake time,3 days awake rate and case fatality rate. Results Average awake time:the treatment group was (9±12)h,the control group was (31±14)h,the treatment group was significantly different from the control group.3 days awake rate:the treatment group:46 cases awake (85.2%),the control group:28 cases awake (53.8%),the treatment group was significantly higher than the control group (P＜0.05). Case fatality rate:the treatment group:4 cases died (7.4%),the control group:18 cases died (34.6%),the treatment group was significantly lower than the control group (P＜0.05). Conclusions Naloxone combined with branched-chain amino acids and ornithine aspartate are one of the effective treatment measures of hepatic encephalopathy. Key words: Hepatic encephalopathy; Naloxone; Branched-chain amino acids; Ornithine aspartate
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