Abstract
Tubule size and the changes of various enzyme activities in response to low doses of HCG were investigated in prepuberal dogs. After administering a total dose of 1000 IU over a period of five weeks, there was no significant alteration of the surface area of the seminiferous tubules as compared to controls. Histochemical studies of a number of hydrolases and oxido reductases of the germinal epithelium and interstitium did not show any changes in activity as compared to those of untreated animals. The results indicate that the low doses of HCG suggested by the International Health Foundation for treatment of cryptorchidism do not lead to marked alterations in the testicular tissue.
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