Abstract
metal nanoparticles have been used to address these diseases in the brain, however very few of these formulations have made it through clinical trials. This review will be discussing the role of noble metal nanoparticles as drug delivery systems specifically to the brain. A common problem many researchers and clinical physicians are facing problems because they are unable to access the brain without highly invasive surgery. Nanoparticles allow access to the brain without invasive surgery. Noble metal nanoparticles (NMNPs) are of particular interest because of their inherent characteristics which are amplified or reduced by ligands. The various ligands available change the method of transportation for a NMNPs traveling through the blood barrier. We will examine various ligands and their benefits and potential drawbacks. Furthermore, the optimal usage for each ligand and associated nanoparticle will also be examined.
 This review will go into detail about pure noble metal nanoparticle, glucose, PEG, CTAB, Transferrin, Anti-Microbial Peptide, and Chitosan as coatings. All of these are commonly used among researchers. The absorptivity into various cell types in the brain along with future implications will be examined.
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