Abstract
In the preceding paper (1) the interest displayed by various workers in the role played by calcium in tumor growth was briefly discussed. It was also shown that injections of a potent parathyroid extract would increase the blood calcium fifty per cent above the normal, with a subsequent increase of calcium in the ash of Flexner rat carcinoma. However, this increased calcium in the circulating blood did not inhibit the growth of the tumor but rather enhanced it, and a number of multiple metastatic tumors were observed. It occurred to the author that inasmuch as irradiated ergosterol produces a deposition of calcium in certain tissues, it would be of interest to study the effect of this vitamin on the growth and calcium content of tumor tissue. Kreitmair and Moll (2) have described the pathological changes produced by “enormous doses” of irradiated ergosterol. Collazo, Rubino and Varela (3) have observed the fatal results of overdosage, as have also Harris and Moore (4) and Light, Miller and Frey (5). These facts led to the adoption of a dosage which would be many times the ordinary amount given but not so great as to be fatal.
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