THE EFFECT OF IMMOBILIZATION STRESS ON SENSORY GATING IN MICE

Abstract

Central sensory filtering processes can be demonstrated using a paired stimulus paradigm. Normal humans show a diminished, vertex-recorded midlatency (50 ms) of auditory evoked potential to the second of paired clicks (0.5 s apart), a phenomenon termed as auditory gating. A loss of 50 ms in auditory gating is strongly related to psychosis. The N40 auditory evoked potential (EP) in rats has been used to develop an animal model for the study of sensory gating mechanisms. Previous animal studies of auditory gating have used psychotomimetic drug administration to induce sensory gating. However, a nonpharmacologic model of deficient gating would be advantageous.In the present study we investigated the effect of immobilization stress on sensory gating in twelve adult male mice. Evoked responses to the paired auditory click stimuli from vertex location of scalp were recorded using a silver needle electrode, a bioelectric amplifier, and an analog-digital converter. The mice were exposed to immobilization stress (IS) for 3 h. Data showed that the N40 potential was depressed in response to the second of the paired stimuli before application immobilization stress. At the end of the 3-h immobilization, the depression of the second N40 response was not observed. It was concluded that sensory gating is present in the mice and acutely disrupted by stressful stimuli, as shown in human subjects and rats