Abstract
Background: Nonalcoholic steatohepatitis (NASH) is part of a broad spectrum of nonalcoholic fatty liver diseases that can lead to cirrhosis. Limited clinical data suggest that Helicobacter pylori (HP) infection might be associated with NASH. Objectives: This randomized double blind clinical trial was designed to determine the short-term effects of HP eradication on liver function tests (LFT) and metabolic profile (biochemical parameters and anthropometric measurements) in a sample of dyspeptic NASH patients. Patients and Methods: Referred dyspeptic patients, with positive antibodies to HP, and the evidence of fatty liver in ultrasonography, were included. After excluding other causes, participants with persistent elevated serum aminotransferase levels were presumed to have NAFLD. Those with NAFLD liver fat score greater than (-0.64) and positive urea breath test (UBT) were enrolled. They were randomly assigned to lifestyle modification alone or lifestyle modification plus HP eradication groups. Quadruple therapy for HP eradication was performed during two weeks. HP eradication was documented by UBT. Liver fat content, fasting serum glucose, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, triglyceride, cholesterol, high and low-density lipoprotein, homeostatic model assessment of insulin resistance and anthropometric measurements (body mass index and waist circumference) were checked at baseline and 12 week post-treatment. Results: One hundred dyspeptic NASH patients (50 male) were enrolled. Their average age in HP treatment group was 36.6 ± 6.4 and 36.7 ± 6.17 years, in control group, respectively. Repeated measure analysis of variance showed a significant reduction in anthropometric measurements and laboratory parameters, in both groups, during the study; however, no significant difference was observed between the two groups, with regard to anthropometric measurements and laboratory parameters, at the end of study. Conclusions: The eradication of HP in dyspeptic NASH patients did not provide any additional improvement in laboratory parameters and anthropometric measurements, compared to lifestyle modification alone.
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