Abstract
Vitamin C is one component that can increase iron absorption in patients with iron deficiency anemia. This study aims to determine the effect of vitamin C supplementation on iron absorption as measured by hemoglobin levels in anemic mice. This type of research is an experimental laboratory design. Experimental animals (Mus. Musculus) male mice were made anemia induced with sodium nitrite and then divided into three treatment groups. Group I, was given distilled water, Group II, was given ferrous sulfate, Group III, was given ascorbic acid + ferrous sulfate at a dose of 4.5 mg. The treatment was given for 14 days after experiencing anemia. Data analysis was used ANOVA test. If it has an effect, it continued with the Duncan Multiple Range Test (DMRT). Changes in the average hemoglobin level of mice ranged from 12-15 grams/dL after 14 days of treatment, which means that the hemoglobin level returned to normal. Thus, the administration of vitamin C can increase iron levels in mice (Mus musculus) Anemia by induction of sodium nitrite.
 ABSTRAK
 
 Vitamin C merupakan salah satu komponen yang dapat menengkatkan absorpsi besi pada penderita anemia defisiensi besi. Penelitian ini bertujuan untuk mengetahui efek pemberian suplementasi vitamin C terhadap absorpsi besi yang diukur dari kadar hemoglobin hewan coba mencit anemia. Jenis penelitian berupa desain laboratory eksperimental. Hewan coba mencit (Mus. Musculus) jantan dibuat anemia dengan diinduksi dengan natrium nitrit kemudian dibagi menjadi tiga kelompok perlakuan. Kelompok I diberi akuades, Kelompok II diberi ferro sulfat, Kelompok III diberi asam askorbat + fero sulfat dengan dosis 4,5 mg. Perlakuan diberikan selama 14 hari setelah mengalami anemia. Analisis data menggunakan ANOVA. Bila memiliki pengaruh maka dilanjutkan dengan uji Duncan Multiple Range Test (DMRT). Perubahan kadar hemoglobin rata-rata mencit berkisar 12-15 gram/dL setelah perlakuan selama 14 hari yang artinya kadar hemoglobin kembali ke keadaaan normal. Dengan demikian, pemberian vitamin C dapat meningkatkan kadar zat besi pada mencit (Mus musculus) Anemia dengan induksi natrium nitrit.
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