The Effect of Giving Mangrove Leaf Extract (Rhizophora apiculata) on the Healing of Burn Wounds in Male White Rats (Rattus novergicus) of the Sprague Dawley Strain

Abstract

A burn wound is damage or loss of tissues caused by contact with a heat source and can be classified into four degrees: I, IIA, IIB, and III. Anti-inflammatory and antioxidant agents such as mangrove leaves can be applied to aid the healing process of burns. One alternative method is to use mangrove leaf extract. This study aims to understand the acceleration of burn healing by applying mangrove leaf extract (Rhizophora apiculata). This study was a true experimental study with a post-test-only control group design, divided into five groups: Knormal (without treatment), K+ (bioplacenton), P1 (20% extract), P2 (30% extract), and P3 (40% extract). Burn wounds were observed for 21 days and assessed with average wound shortening, healing time, and the Bates-Jensen wound assessment tool. Based on the results of statistical tests, it was found that the application of Rhizophora apiculata leaf extract affected the healing of burns in white rats, resulting in a reduction in the burn area (P Value: 0.001). The application of mangrove leaf extract had an effect on the healing time of burns in white rats (P Value: 0.001). An effective dose of mangrove leaf extract was a concentration of 40% for healing burns, a higher effectiveness in healing burns compared to the standard drug, bioplacenton. The administration of mangrove leaf extract positively affects the healing of burns in male white rats (Rattus novergicus) of the Sprague Dawley strain, especially with an extract concentration of 40%.