Abstract
Sodium linoleate was found to significantly decrease direct migration inhibition (DMI) of leukocytes taken from healthy subjects that displayed a vigorous DMI response to paramyxoviral antigens (measles and parainfluenza Type 1) and to increase reactivity of leukocytes from subjects with poor response to these antigens. Similar effects were found with sodium arachidonate, PGE 1, and PGE 2, but not with sodium oleate. Linoleate was found to exert its effects through its conversion to prostaglandins by a nonglass-adherent mononuclear subpopulation of the white blood cells.
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