Abstract
It has recently been reported from this laboratory that ethanolamine inhibits the release of SRS-A (slow-reacting substance of anaphylaxis) in sensitized guinea pigs lungs injected with specific antigen. The known effects of ethanolamine on phospholipid synthesis and turnover thus prompted an investigation of the effects of anaphylaxis on the lipid content of guinea pig lungs and the influence thereon of anti-anaphylactic doses of ethanolamine. Anaphylaxis caused alterations in the lipid content of sensitized lungs, especially the triglyceride, cephalin, lecithin and sphingomyelin fractions. Lungs from animals which had been pretreated with ethanolamine and which had liberated no SRS-A during anaphylactic shock showed smaller alterations in their lipid content.
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