Abstract
ALTHOUGH the effects of estrogen on the thyroid physiology of mammalian species, especially laboratory rodents, have been extensively investigated, similar studies on avian species have been meager and have led to equivocal conclusions. Considering the importance and apparent complexity of thyroid-ovarian interactions, especially in the reproductive physiology of birds, extension of these studies is warranted. The present study was undertaken to investigate the effects of estrogen on thyroid activity (i.e., on the pituitary-thyroid axis) in the immature domestic fowl.MATERIALS AND METHODSAll experimental animals were male Single Comb White Leghorn chicks, produced by the Departmental flock. They were selected, brooded and necropsied according to described techniques (Burger et al., 1962), designed to permit statistical separation of as much as possible of the inevitable spurious variance.The experimental drugs—thiouracil, iodinated casein (Protamone) and dienestrol diacetate (DD)—were incorporated in the standard basal diet, and thyrotropic hormone (TSH) was dissolved …
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