Abstract
FOR SOME TIME it has been known that estrogens produce fluid accumulation in the uterus of experimental animals. Although the length of the latent period following estrogen administration (1) and the electrolytic shifts involved (2) have been evaluated, the mechanism by which the edema reaction proceeds is obscure. In general, the principal factors which favor enhanced fluid accumulation have been listed as follows (3): (a) increases in the capillary pressure, (b) increases in the permeability of the capillary membranes, (c) reduction in the osmotic pressure of plasma as compared to tissue fluid, (d) obstruction of the lymph channels. To produce uterine edema, estrogen must set into motion one or more of the above factors or some new mechanism hitherto not described. In an attempt to elucidate the mechanism of the uterine fluid accumulation induced by estrogen, we have tried to evaluate, in part, the effect of estradiol benzoate on the factors producing edema.
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