Abstract
BackgroundAnastomotic leakage is an important problem following primary resection in the left colon and is even more prominent when obstruction is present. We aimed to evaluate the possible effects of erythropoietin on the healing of anastomosis under both obstructive and non-obstructive states.MethodsForty male Wistar albino rats were divided into four groups. In group I, two cm left colonic resection and primary anastomosis were done. In group II, left colon were completely ligated and 24 hours later animals were re-operated for segmental resection. The same procedures were performed for rats in group III and IV in respect to group I and II and, 500 IU/kg a day erythropoietin were given in the latter two groups for seven days. For the quantative description of anastomotic healing mechanical, biochemical and histopathological parameters were employed on the seventh day and the animals were sacrificied.ResultsAlthough erythropoietin had positive effects on bursting pressure in group IV when compared to group II, it has no effect in group III. Despite the increased tissue hydroxyproline levels in group IV, erythropoietin failed to show any effects in group III.Erythropoietin had positive effects on neovascularization, fibroblast proliferiation and storage of collagen in group IV.ConclusionWe failed to find any direct and evident effects of erythropoietin on healing of left colonic anastomosis. On the other hand, erythropoietin might prevent negative effects of obstruction on healing.
Highlights
Anastomotic leakage is an important problem following primary resection in the left colon and is even more prominent when obstruction is present
Dehiscence of intestinal anastomosis remains a major complication after gastrointestinal tract surgery
World Journal of Emergency Surgery 2007, 2:13 http://www.wjes.org/content/2/1/13 tional state, the localization and type of operation, the patient's age, the presence of obstruction and whether the operation was elective or emergency, which may effect the success of anastomotic healing have been studied [1,2,3]
Summary
Anastomotic leakage is an important problem following primary resection in the left colon and is even more prominent when obstruction is present. We aimed to evaluate the possible effects of erythropoietin on the healing of anastomosis under both obstructive and non-obstructive states. The anastomotic dehiscence and leakage that occurs as a result of it may lead to high rates of morbidity and mortality. World Journal of Emergency Surgery 2007, 2:13 http://www.wjes.org/content/2/1/13 tional state, the localization (left colon or right colon) and type of operation, the patient's age, the presence of obstruction and whether the operation was elective or emergency, which may effect the success of anastomotic healing have been studied [1,2,3]. All anastomosis were performed using interrupted 6/0 polypropylene sutures, (Prolene, Ethicon, UK) in a singlelayer, end to end and extramucosal manner. The abdomen was closed with interrupted 3/0 silk sutures (Dogsan, Trabzon, Turkey)
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