Abstract
Microcirculatory dysfunction plays an important role in sepsis-related multiple organ dysfunction.(1) Several studies has shown polymyxin B hemoperfusion has favorable effects on mean arterial pressure, vasopressor use, and mortality.(2) One rat sepsis study had found that microcirculation was better maintained in the polymyxin B hemoperfusion group.(3) However, the effects of polymyxin B hemoperfusion on the microcirculation of the intestinal mucosa, intestinal muscular-serosal layer, kidney, and liver were unknown. We used a fecal peritonitis-induced septic pig model to investigate the effect of polymyxin B perfusion on the microcirculation.
Highlights
Microcirculatory dysfunction plays an important role in sepsis-related multiple organ dysfunction.(1) Several studies has shown polymyxin B hemoperfusion has favorable effects on mean arterial pressure, vasopressor use, and mortality.(2) One rat sepsis study had found that microcirculation was better maintained in the polymyxin B hemoperfusion group.(3) the effects of polymyxin B hemoperfusion on the microcirculation of the intestinal mucosa, intestinal muscular-serosal layer, kidney, and liver were unknown
The hemodynamic parameters were shown in the Table 1
The perfused small vessel density (PSVD) of the terminal ileal mucosa in the septic pigs was less than the non-septic pigs at 0h (24.3 mm/mm[2] vs. 30.0 mm/mm[2], p = 0.005)
Summary
Microcirculatory dysfunction plays an important role in sepsis-related multiple organ dysfunction.(1) Several studies has shown polymyxin B hemoperfusion has favorable effects on mean arterial pressure, vasopressor use, and mortality.(2) One rat sepsis study had found that microcirculation was better maintained in the polymyxin B hemoperfusion group.(3) the effects of polymyxin B hemoperfusion on the microcirculation of the intestinal mucosa, intestinal muscular-serosal layer, kidney, and liver were unknown. We used a fecal peritonitis-induced septic pig model to investigate the effect of polymyxin B perfusion on the microcirculation
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