Abstract
1. 1. Thermal responses to i.v. administration of doxazosin (0.75 or 1.50 mg/kg), urapidil (5.0 or 10.0 mg/kg), or indoramin (0.75 or 1.50 mg/kg) were investigated in febrile rabbits (treated with Escherichia coli lipopolysaccharide) at an ambient temperature of 19 ± 1°C. 2. 2. All these α 1-adrenoceptor blockers produced statistically significant antipyresis which developed as a result of inhibition of metabolic heat production and/or stimulation of heat elimination from the ear skin area or respiratory tract. 3. 3. It appears that the antipyretic effect is a general feature of α 1-adrenergic receptor blockers. The possible mechanisms by which antipyresis is produced are being considered.
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