Abstract
Background: We recently have developed a new DNA/RNA heteroduplex oligonucleotide (HDO) with a structure of DNA/locked nucleotide acid gapmer antisense oligonucleotide (ASO) duplexed with a α-tocopherol conjugated complementary RNA strand (Toc-cRNA), and showed its high potency of gene silencing in liver compared to any kind of previously reported ASOs and siRNA at orders-of-magnitude. (Nishina K, et al. Nat Commun, 2015).
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
