Abstract
While the pathophysiology of chronic disorders varies there are three basic mechanisms - inflammation, oxidative stress and endothelial dysfunction – that are common in many chronic diseases. However, the failure of these mechanisms to work synchronously can lead to morbidity complicating the course of many chronic diseases. We analyzed data of 178 patients from cohorts with selected chronic diseases in this quasi-experimental study. Endothelial dysfunction was determined by flow-mediated dilatation (FMD) and asymmetric dimethylarginine (ADMA) levels. Serum ADMA, high sensitive C-reactive protein (hs-CRP), serum PTX3, malondialdehyde (MDA), Cu/Zn-superoxide dismutase (Cu/Zn-SOD), glutathione peroxidase (GSH-Px) levels and FMD were studied in baseline and after 12 weeks of Morinda citrifolia (anti-atherosclerotic liquid- AAL), omega-3 (anti-inflammatory capsules- AIC) and extract with Alaskan blueberry (anti-oxidant liquid- AOL). Stepwise multivariate regression analysis was used to evaluate the association of FMD with clinical and serologic parameters. Serum ADMA, MDA, PTX3, hsCRP and albumin levels, and proteinuria were significantly decreased while CuZn-SOD, GSH-Px and FMD levels were significantly increased following AAL, AIC and AOL therapies. The FMD was negatively correlated with serum ADMA, MDA, PTX3, and hsCRP levels and positively correlated with CuZn-SOD and eGFR levels. ADMA and PTX3 levels were independently related to FMD both before and after AAL, AIC and AOL therapies. Our study shows that serum ADMA, MDA, PTX3 levels are associated with endothelial dysfunction in patients with selected chronic diseases. In addition, short-term AAL, AIC and AOL therapies significantly improves a number of parameters in our cohort and can normalize ADMA, PTX3, hsCRP and MDA levels.
Highlights
Chronic diseases are the leading causes of death in developed countries, with atherosclerosis and its complications at the top of the list
We aimed to pursue this question by testing the hypothesis that improvement in FMD in patients with chronic diseases whose pathophysiology involves oxidant stress and inflammation following initiation of anti-atherosclerotic liquid (AAL), anti-inflammatory capsules (AIC) and anti-oxidant liquid (AOL) therapies is directly linked to the relative reduction of inflammatory, oxidative stress and endothelial dysfunction markers, especially pentraxin 3 (PTX3), MDA and asymmetric dimethylarginine (ADMA)
We report the results of an open-label 12-week trial investigating the impact of initiation of AAL, AIC and AOL therapies in chronic diseases
Summary
We aimed to pursue this question by testing the hypothesis that improvement in FMD in patients with chronic diseases whose pathophysiology involves oxidant stress and inflammation following initiation of anti-atherosclerotic liquid (AAL), anti-inflammatory capsules (AIC) and anti-oxidant liquid (AOL) therapies is directly linked to the relative reduction of inflammatory, oxidative stress and endothelial dysfunction markers, especially pentraxin 3 (PTX3), MDA and asymmetric dimethylarginine (ADMA)
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