Abstract
(Int J Obstet Anesth. 2015;24:217–224) Oxytocin administration following cesarean delivery may be associated with significant adverse effects, such as cardiovascular instability (hypotension, tachycardia, myocardial ischemia). Intravenous (IV) calcium chloride (CaCl2) has been shown to increase mean arterial pressure (MAP) and cardiac contractility in patients undergoing anesthesia. Consequently, the authors of the present study hypothesized that IV co-administration of CaCl2 with oxytocin 5 U IV bolus would reduce the risk of hypotension and improve uterine tone in women undergoing elective cesarean delivery under spinal anesthesia. The primary outcome studied was blood pressure change after study drug administration. Secondary outcomes included the effect of CaCl2 on heart rate, uterine tone, need for additional uterotonic agent, vasopressor use, and blood loss.
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