Abstract
3542 Background: The impact of the duration of chemotherapy on the overall survival (OS) of patients with metastatic colorectal cancer (mCRC) is controversial. We performed a systematic review and meta-analysis of randomized controlled trials (RCT) that compared chemotherapy continuously administered until progression versus complete treatment interruption after first line therapy for patients with mCRC Methods: We searched medical literature databases and oncology conferences proceedings for RCTs that compared the OS of mCRC patients who received first line chemotherapy until progression with those who were offered complete treatment stop after a fixed number of cycles. RCT that evaluated the role of any kind of maintenance therapy were excluded. A meta-analysis of reported Hazard Ratios for OS, with respective 95% confidence intervals, was performed using the fixed-effect models. Results: Our search retrieved 106 trials, of which sox were eligible (N=2373). The meta-analysis (N=2,334) showed a statistic...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
