Abstract
Lymphocytes in culture from human volunteers on a regimen of 800 mg of caffeine daily (4×200 mg) for one month manifested no significant increase in chromosome damage. The highest level of caffeine in the plasma was 30 μg/ml. Multiple exposures of lymphocyte cultures from other untreated donors to this concentration (30 μg/ml) was also without chromosome-damaging effect. However, single exposure of cells at the 48th h of culture produced damage in the 250–750 μg/ml range. These findings were the result of experiments with the lymphocytes from the same four individuals tested on three separate occasions. Earlier additions at concentrations below 250 μg/ml produced no significant breakage.
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