Abstract
Summary o 1. Under the conditions of these experiments, there is no evidence that the administration of a bacterial endotoxin favorably affects normal repair by connective tissue as measured by the formation of collagen, gain in tensile strength or rate of contraction. In fact, in repeated doses it may inhibit repair. 2. A suboptimal rate of growth as observed around implanted plastic sponges is stimulated by the administration of endotoxins in appropriate doses. 3. This study provides additional evidence that there is a specific relation between the initial inflammatory response to injury and the rate of connective tissue formation. There appears to be an optimal inflammatory response beyond which stimulation is deleterious.
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