Abstract
AbstractThe effects of hypoxemia on the acid‐base parameters of the arterial blood and CSF were studied in anesthetized constant ventilated rats. The results showed that there was a one to one relationship between the increase in the CSF lactate and the decrease in the CSF bicarbonate concentration over a wide range of arterial Po2 values. However, the decrease in the CSF pH at constant ventilation was much less than could be expected from the decrease in bicarbonate. This was due to a concomitant fall in the CSF CO2 tension, partly caused by a fall in the arterial CO2 tension and partly by a decrease in the Po2 difference between CSF and arterial blood.
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