Abstract
Objective To study the effect of anti-EGFR monoclonal antibody (MMAb-2) therapy on the growth of pancreatic cancer cells in combination with chemotherapeutic agent. Methods A tumor cell suspension (SW1990) was injected into the subcutaneous dorsa of mice in the proximal tnidline. The treatment groups received intraperitoneal injections of MMAb-2 or 5-Fu or gemcitabine or MMAb-2,5-Fu and gemcitabine in combination respectively. The control group only received intraperitoneal injection of saline. After 4 weeks for treatment, the mice were killed. Results The inhibition ratio of proliferation of pancreatic tumor cells was increased evidently by 5-Fu,gemcitabine in combination with MMAb-2 (P<0.05). Conclusion The MMAb-2 could enhance significantly the sensitivity of the cyto-inhibition of the chemotherapeutic agents on pancreatic tumor cells,and improve the chemotherapeutic effects of pancreatic cancer cells. Key words: Pancreatic carcinoma; Epidermal growth factor receptor; Monoclonal antibody
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
