Abstract
VARIOUS ammonium salts have been used to induce pulmonary oedema in different species including the rat1. The role of histamine in this process is obscure. Some investigators have presented evidence of a protective action of an antihistaminic drug, while others have failed to show it2. Garan3 showed that ammonia vapour liberated histamine from the guinea-pig's lung. Schild4 found that ammonium chloride released histamine from the isolated rat diaphragm, which process seemed to depend on the pH of the solution bathing the muscle. Luisada5, however, could not find certain proof that histamine or acetylcholine produced in the lung led to oedema.
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