Abstract
Abstract In the present experiments, erythropoietin production and the rate of erythropoiesis after the infusion of aldosterone were studied. Adrenalectomized and nonadrenalectomized rats were exposed to atmospheric pressure of 405 mm. Hg (5,000 M.) or to normal atmospheric pressure for a period of 6 hours. The control group of rats was given saline, the second group of rats was given aldosterone diluted in saline. Erythropoietin activity of rat plasma was tested on hypertransfused mice. Erythropoietin production in adrenalectomized hypoxic rats was stimulated by the high doses of aldosterone 60 and 70 μg per rat, however, it was not influenced by the low doses 2 and 20 μg per rat. In nonadrenalectomized hypoxic rats and in adrenalectomized rats in normal atmospheric pressure, erythropoietin production was not changed by the high dose of aldosterone 70 μg per rat. Aldosterone did not influence the rate of erythropoiesis in the normal and polycythemic mice. Oxygen consumption of the kidney, determined in vitro, after 6 hours infusion of aldosterone 70 μg per rat in adrenalectomized rats was significantly increased. The results support the view that the receptors of an erythropoietic stimulus are in the kidney tissue and may be localized in the cells of renal tubules. Changes in the ratio of oxygen supply to oxygen demand in kidney tissue influence the erythropoietin production.
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