Abstract
The possibility has been suggested that prolactin may interact with adrenal hormones to affect renal function in addition to the evidence indicating a direct effect on the kidney. Burstyn, Horrobin, and Manku (1972) and Horrobin, Manku, and Burstyn (1973) have shown that aldosterone can induce a natriuresis in the presence of excess salt intake or excess Cortisol and that this natriuresis can be reversed by prolactin injection. Moreover, Relkin and Adachi (1973) have suggested that prolactin is necessary for the enhanced aldosterone secretion rates observed in sodium-deprived rats. These studies indicated that prolactin must be present, at least under certain conditions, in order for aldosterone to induce an antinatriuretic effect. Whether aldosterone is necessary for prolactin to affect kidney function is not known. An experiment was designed, therefore, to determine if the adrenals, i.e. aldosterone, must be present for the renal effects of prolactin to occur.KeywordsUrine FlowRenal ResponseAdrenal HormoneExcess CortisolExcess Salt IntakeThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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