Abstract
Acute hypoxia induced by the administration of sodium nitrite was found to result in the reduction of glucokinase activity in the tissue. Single ACTH administration in a dose of 2 units depressed the glucokinase activity in the muscles, without affecting the activity of the enzyme in the brain and the testes. Preliminary single ACTH administration prevented the inhibition of glucokinase activity in the brain as observed in hypoxia. Repeated preliminary ACTH injections (2 units daily for 6 days) did not affect the rate of glucokinase reaction in the muscles and the brain, and reduced the glucokinase activity in the testes; the injections also normalized the muscle glucokinase activity inhibited in conditions of hypoxia.
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