Abstract
Problem statement: there are controversies about the effects of anti-inflammatory drugs on exercised induced changes on plasma cytokines in untrained male athletes, so the primary purpose of this study was to measure the influence of a prophylactic dose of ibuprofen use on plasma cytokines during a 1500 m running race. Approach: Subjects were 10 untrained male Medical University students who consumed 400 mg ibuprofen two hours before the 1500 m running practice and 10 controls that competed in the race but avoided ibuprofen and all other medications. Blood samples were collected before, 1h and 24 h following the 1500 m exercise bout to measure plasma concentrations of interleukin-1 beta (IL-1β ), interleukin-6(IL-6) and tumor necrosis factor alpha (TNF- α ). Results: There were not any significant differences between plasma concentration of IL-1β, IL-6 and TNF- α during the study period. Also the data showed that there were not any significant differences between plasma level of IL-1β, IL-6 and TNF- α in ibuprofen and control group during the study period. Conclusions/Recommendation: Our result showed that a prophylactic dose of ibuprofen did not affect acute inflammatory cytokines levels (IL-1β, IL-6 and TNF- α) in untrained healthy young males. So the etiology of the muscle soreness in athletes actively participating in sport races seems to be independent of inflammatory processes.
Highlights
It has been documented that strenuous exercise induces pyrogenesis and elicits mobilization and functional augmentation of neutrophils and monocytes whereas it suppresses cellular immunity leading to increased susceptibility to infections (Shephard et al, 1994)
Tumor Necrosis Factor Alpha (TNF- α) level was significantly higher in a heavy-exercise in healthy young men performed bicycle ergometer exercises
The increase in plasma cytokine levels has been reported in athletes competing in marathons and ultramarathons, long term bicycle exercise and athletes actively participating in sport races (Nieman, 1998; Ostrowski et al, 2000; Suzuki et al, 2002)
Summary
It has been documented that strenuous exercise induces pyrogenesis and elicits mobilization and functional augmentation of neutrophils and monocytes whereas it suppresses cellular immunity leading to increased susceptibility to infections (Shephard et al, 1994). The increase in plasma cytokine levels has been reported in athletes competing in marathons and ultramarathons, long term bicycle exercise and athletes actively participating in sport races (Nieman, 1998; Ostrowski et al, 2000; Suzuki et al, 2002) These observations indicate that and informed consent was obtained from the subjects. The difference between groups was determined by analysis of variance anti-inflammatory drugs on exercised induced changes (ANOVA), followed by the Tukey's post hoc test with on plasma cytokines in untrained male athletes, so the 5% level of significance (p
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