Abstract
The effect of 4, 4'-methylenedianiline on the adrenocortical secretion in the rat was investigated. Under sodium pentobarbital anesthesia, adrenal venous blood was collected through a polyethylene cannula inserted into the adrenal vein and analyzed for corticosterone. 4, 4'-Methylenedianiline dihydrochloride was administered intravenously in a dose of 100mg/kg. In non-hypophys-ectomized rats, the increased corticosterone secretion in response to surgical stress caused by the adrenal vein cannulation was markedly depressed following the injection of methylenedianiline. A low secretion rate of corticosterone persisted for 30 minutes thereafter. In hypophysectomized rats, the increased corticosterone secretion produced by intravenous infusion of ACTH was also markedly depressed by injection of methylenedianiline. It is thus concluded that in the rat the adrenal corticosterone secretion is depressed by 4, 4'-methylenedianiline and that this inhibitory effect on adrenal corticosterone secretion is due to a direct action of the drug on the adrenal cortex.
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