Abstract
This study evaluated the effects of 2.4-D, of the propylene glycol butyl ether ester of 2.4-D (PGBE) and of the isooctyl ester of 2.4-D (IO) on foetal development and neonatal growth and survival. Dose levels of 2.4-D up to a maximum tolerated dose of 87·.5 mg/kg4day or molar equivalents of PGBE or IO were administered to pregnant Sprague-Dawley rats on days 6–15 of gestation. Foetuses were delivered by Caesarean section on day 20 of gestation and were examined grossly, measured and weighed. Following routine preparations, the soft tissues and skeletons were examined. Signs of embryotoxicity and foetotoxicity, such as decreased foetal body weight, subcutaneous oedema, delayed ossification of bone, lumbar ribs and wavy ribs were observed at high dose levels; considered overall, the responses were dose-related. Teratogenic effects, however, were not seen at any dose level. 2.4-D did not affect fertility, gestation, viability or lactation. PGBE and IO had no effect on fertility and gestation indices, but the highest dose levels decreased viability and lactation indices. Neonatal growth and development were not altered by treatment during pregnancy.
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