Abstract
AbstractFamotidine was found to form an inclusion complex with 2-hydroxypropyl-s-cyclodextrin (HPCD). Phase-solubility diagram was classified as type AL with a stability constant for complex formation (Kst) of 100.50 M1 at pH 7.4. Famotidine undergoes specific acid catalysis in strongly acidic solutions. Addition of HPCD to these solutions decreased the rate of drug degradation. The rate constant for degradation of complexed famotidine (kc) and Kst were estimated from the relationship between the observed rate constant for overall drug degradation (Kobs) and HPCD concentration. An increase in ionization of famotidine resulted in a decrease in the magnitude of Kst. The dissolution rate of the prepared complex was significantly greater than that of the pure drug.
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