Abstract
<b>Introduction:</b> Pertussis disease burden in adults is high, but the role of age on its economic burden is unknown. <b>Aims and objectives:</b> To estimate the economic burden of pertussis among ≥50-year-olds in England, from 2009 to 2018, stratified by age. <b>Methods:</b> Post-hoc exploratory analysis on retrospective observational study data of the Clinical Practice Research Datalink database and the Hospital Episode Statistics. Health care resource utilisation (HCRU) and associated annualized direct medical costs (DMC) were compared between matched groups of adults with and without pertussis diagnosis, stratified by age groups, before and after diagnosis date. Costs were adjusted for inflation. <b>Results:</b> Baseline HCRU and DMC were similar among pertussis patients and matched controls in all age groups. Rates of general practitioner and nurse visits were consistently higher in the pertussis cohort compared to controls in all age groups between 6 months before up to 2 months after diagnosis. Also, the total mean annualized DMC between 1 month before and 11 months after diagnosis, were higher in the pertussis cohort compared to the controls and increased with age (Table). <b>Conclusions:</b> A pertussis episode resulted in significant increase in HCRU and DMC around the diagnosis time for different age groups. HCRU and associated DMC tended to increase with age.
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