Abstract
Objective Purpose To detect the expression of E-cadherin in colorectal carcinoma and lymph node micrometastases,and investigate their relationship.Methods 82 cases of lymph node simple was dectected with RT-PCR method using CK20 mRNA acridinium ester.in screening colorectal carcinoma lymph node micrometastases.E-Cadherin expression analysed by immuno-histochemical staining(the SP method) in colorectal cancer tissue,tissue nearby cancer,the normal control tissue.Results In 60 cases of colorectal carcinoma,the expression of E-Cadherin was 71.67%.Number of positive nodes was 55.8%,the expression of E-cadherin was 56.7%(34 cases) and number of positive nodes was 45.5%(356 cases) through routine pathological examination.The low level expression of E-Cadherin was positively correlated with the Dukes staging,serosa infiltration,lymph node and liver metastasis of colorectal carcinoma(x2 = 16.72,P ＜ 0.05).The expression of E-Cadherin was negative in 6 of the 11 patients with lymph node micrometastases,and in 6.67% 1 of the 15 patients without lymph node micrometastases(x2 = 4.160,P = 0.041).Conclusion The negative expression of E-Cadherin may contribute to lymph node micrometastases in colorectal carcinoma. Key words: colorectal carcinoma; E-Cadherin; Lymphatic metastasis; Rt-pcr
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