The disturbance of vascular permeability in burns. An electrophoretic investigation of the protein content of lymph flowing from the burned area

Abstract

Electrophoretic investigations of the lymph draining from burned rabbits' paws were performed. It was established that the concentration of protein increases within the first hour after the burn and an additional β-globulin fraction (β2-globulin) appears. In 24 hours, the derangement of the protein content of the lymph is even more pronounced, i.e., the concentration of protein increases, the relative content of albumin diminishes, β2-globulin fraction is still present and the level of α2-globulin is also raised. In accordance with literature data on the effect of active β-globulins on the local capillary permeability the author suggests that these proteins play an important role in the appearance of general disturbances of capillary permeability in the areas free from inflammations. These disturbances were revealed by the author in experimentally induced inflammation in rabbits and dogs. They were described in his previous papers.