The Diagnostic Value of Combined Detection of Kidney Injury Molecule-1 and Urine Microsomal Protein in Early Stage Nephropathy of Gestational Hypertension

Abstract

To investigate the diagnostic value of urine kidney injury molecule-1 and urine microsomal protein combined test in early stage nephropathy of gestational hypertension. 72 patients with gestational hypertension treated at the hospital from December 2018 to December 2019 were randomly selected as subjects and 72 normal pregnant women who gave birth at the hospital during the same period were randomly selected as controls. Urinary microsomal protein levels were measured by immune enhanced turbidimetric assay, while urinary kidney injury molecule-1 levels were measured by enzyme linked immunosorbent assay. Blood urea nitrogen, high-sensitivity C-reactive protein levels, and specificity and sensitivity of urine kidney injury molecule-1 and urine microsomal serum proteins in the two groups and their subgroups were analyzed comparatively. The levels of urinary kidney injury molecule-1 and urinary microsomal serum protein were higher in the study group than in the control group. Among the three subgroups of the study group, urinary kidney injury molecule-1 and urinary microsomal serum protein levels were significantly increased in the mid and late pregnancy groups compared to the early pregnancy group. In the subgroup with impaired renal function, the urinary kidney injury molecule-1 and urinary microalbumin levels were significantly higher than those in the subgroup with normal renal function and the difference was statistically significant (p<0.05). In terms of blood urea nitrogen and high-sensitivity C-reactive protein levels, blood urea nitrogen and high-sensitivity C-reactive protein levels in the study group were higher than those in the healthy control group and estimated glomerular filtration rate was lower than those in the healthy control group. Urinary kidney injury molecule-1 level and urinary microsomal protein in the study group showed positive correlation with blood urea nitrogen and high-sensitivity C-reactive protein (both p<0.05), and negative correlation with Estimated glomerular filtration rate. In terms of sensitivity and specificity, the results showed that the specificity and sensitivity of the combined test were significantly higher than that of the individual test and the difference was statistically significant (p<0.05). The detection of serum kidney injury molecule-1 and microsomal protein and other indicators to determine the degree of early renal impairment in pregnancy induced hypertension is beneficial for early clinical treatment and is of great clinical significance for pregnant women and pregnancy outcomes.