Abstract
In this study, the stability constants of the cobalt(II), zinc(II), cadmium(II) and copper(II) complexes of finasteride were determined potentiometrically by using Irving-Rossotti and Calvin-Bjerrum methods and supported by spectrophotometric way [1,2,3]. The evaluated protonation constant of finasteride was found as logK=2.21. Potentiometrically the logarithms of the stability constants of the finasteride-metal complexes were found by Calvin-Bjerrum and Irving-Rossotti methods: for cobalt(II) complex logK=3.01; for zinc(II) complex logK=2.82; for cadmium(II) complex logK=3.04 and for copper complex logK=2.85 at 25oC (I=0.10). Conditional formation constants of the complexes were calculated and pH ranges of the complexation were found. Spectrometric measurements were recorded for cobalt(II)-finasteride, zinc(II)-finasteride, cadmium(II)-finasteride and copper(II)-finasteride solutions and the results of the measurement supported the formation of complexes.
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