Abstract
The problem of determining tumour time-dose isoeffect (Strandqvist, 1944) curves from clinical data has been examined. Initially a detailed discussion of the basic factors underlying the observed results is presented, making use of current radiobiologic concepts. A multiple probit analysis technique is then described for clinical data, and when applied to published results from Hodgkin's disease indicates that the time-dose curve may really be flat. A mathematical model is developed which allows prediction by use of the Monte Carlo technique of the outcome of clinical trials for any given actual time-dose response characteristics and any pattern of choosing treatment conditions. The pitfalls in the traditional methods of analysis of such data can then be shown explicitly and the power of the multi-probit curve method demonstrated. The importance of accurate time-dose data is stressed and the suggestion made that a complete re-evaluation of current concepts may be the most promising approach to improve clinical results in radiation therapy.
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