Abstract
Studies of the nature of the antibodies associated with isologous skin sensitizing activity have indicated the presence of a previously unrecognized immunoglobulin in human serum. The immunoglobulin was identified by virtue of specific antigenic determinants. Independently, a protein with similar antigen characteristics was identified both in the serum of a patient with multiple myeloma and in normal serum. It is proposed that the normal protein and antigenically related myeloma proteins shall be designated IgE or γE, and the heavy polypeptide chains of these molecules be designated ε (epsilon)-chains, in accordance with Nomenclature for Human Immunoglobulins. This replaces the previous usage of γE-globulin and IgND.
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