Abstract
The present study was performed to explore the curative effect of Methylsulfonylmethane (MSM) in an experimental model of myoglobinuric acute renal failure (ARF). In this experimental model, Rats were injected with 50% glycerol (10 mL/kg, im) followed by an hour later and daily in the next six days by MSM (400 mg/kg) or saline. Kidney’s function (urea and creatinine), and reduced glutathione were analyzed. A renal failure produced by glycerol injection, with a significant increase of blood urea and serum creatinine was observed. Rats that received MSM in addition to glycerol had significantly lower blood urea and serum creatinine levels compared to those receiving glycerol alone. However, glutathione has markedly increased after MSM treatment. The effect is probably due to the antioxidant activity of MSM. This may provide therapeutic opportunities for treating humans, myoglobinuric ARF.
Highlights
Methyl Sulphonyl Methane, better known as MSM, is a naturally occurring Sulphur compound with well-known antioxidant properties (Marañón et al, 2008)
Treatment of animals with MSM significantly reduced the levels of urea (51 ± 6.261 mmol/L) for the (M) group compared with that of (G) rats
Reduced Glutathione levels The administration of glycerol significantly reduced the concentration of endogenous antioxidant glutathione as compared to control group
Summary
Methyl Sulphonyl Methane, better known as MSM, is a naturally occurring Sulphur compound with well-known antioxidant properties (Marañón et al, 2008). MSM may be effective for the treatment of pain syndromes, athletic injuries, bladder disorders, hyperacidity, constipation, musculoskeletal pain, allergies, and for immunomodulation (Parcell, 2002), osteoarthritis pain, inflammation, repetitive stress injuries, induce wound healing, bladder disorders like intestinal cystitis (Childs, 1994), parasitic infections and the maintenance of normal keratin levels in hair, skin and nails (Horvath et al, 2002). Acute renal failure (ARF) is a syndrome distinguished by an acute loss of renal function. Mortality from ARF remains high (over 50%), despite the reversibility of this loss in most patients who survive. The search for effective therapy to accelerate recovery and attempts to prevent ARF has attracted much attention (Park et al, 2012)
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