Abstract
Extrathermodynamic relationships between the octanol-water and polymer-water partition coefficients of a number of solutes in 6 polymer-water systems were established: log P (polymer-water) = a log P (octanol-water) + b The solutes were steroids, narcotic amines, and one barbiturate, with log P oct values incrementally spanning the range from 1 to 4. The polymers were 5 rubbery polymers ( T g < 37°C), polyethylene, polydimethylsiloxane, polyethylene-co-vinyl acetate, poly-ε-caprolactone, and poly-ε-caprolactam-co-ε-caprolactone, and one hydrogel, poly-2-hydroxyethyl methacrylate, with solubility parameters increasing from 15.1 to 25.5 J 1/2. cm 3/2. The slopes and intercepts of the correlation equations were shown to be proportional to the polymer polarity and to the logarithm of the solubility of water in the polymers, respectively. The log P correlations provided a means of estimating the relative solubilities of a new polymer ab initio. When combined with calculated or known aqueous drug solubilities, the correlations could be used to estimate absolute drug solubilities in a polymer.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
