Abstract
There is evidence for two intrarenal receptors in the control of renin release. The renal vascular receptor appears to be located in the renal afferent arterioles in the region of the juxtaglomerular cells and to respond to changes in wall tension. The macula densa is apparently a sodium-sensitive receptor, but the precise signal perceived remains unknown. Available data suggest a primary role for the renal vascular receptor in renin release. The renal nerves exert a modulating influence on renin release but are not essential for hypersecretion to occur; evidence favors a beta receptor for mediation of the renal nerve mechanism. Finally, a number of humoral agents, including epinephrine and norepinephrine, sodium and potassium ions, antidiuretic hormone and angiotensin II, influence renin release.
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