Abstract
Objective To evaluate the expression of human leucine-rich repeats and immunoglobulin like domainsl (LRIG1) mRNA in astrocytoma and its correlation with epidermal growth factor receptor (EGFR) mRNA and tumor malignancy in order to investigate its role of LRIG1 in the oncogenesis. Methods The expression of LRIG1 and EGFR mRNA in 35 cases of astrocytomas with grades I-IV was detected by RT-PCR,and analyzed statitiscally. Results There was weak expression of LRIG1 mRNA (27/35) ,and over-expression of EGFR mRNA (21/35) in most astrocytomas. There was no significant difference in the LRIG1 mRNA expression between low grade (Ⅰ～Ⅲ) (18 cases) and high grade (Ⅲ～Ⅳ) (17 cases) astrocytomas (P > 0. 05) , but there was significant difference in the EGFR mRNA expression between them. There was no significant correlation between the expression of LRIG1 mRNA and EGFR mRNA (r = 0. 187, P > 0.05). Conclusion As a feedback negative attenuator of EGFR signaling, the LRIG1 mRNA was down-regulated, suggesting its contribution to the oncogenesis of astrotoma. However, there was no significant correlation of the LRIG1 mRNA with EGFR mRNA and tumor malignancy, indicating LRIG1 might be the early influencing factors responsible for the pathogenesis of astrocytoma. Key words: Astrocytoma; EGFR; Transcription
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