Abstract
An accurate diagnosis of melanomas at an early stage correlates directly with a better prognosis. However the incidence of melanoma is still increasing along with the number of related deaths. Melanoma cells grow extremely fast, with the result that many patients present after metastasis has occurred, too late for effective treatment. This paper describes the changes in the fibre diffraction patterns of skin that indicate the presence of a melanoma. Identification of these changes would provide an alternative early low-cost, reliable diagnostic test which could be conducted on a regular basis in local radiology facilities using rotating anode X-ray generators or as a mass screening test using suitable small angle x-ray beam-lines at synchrotrons.
Highlights
Melanomas are the most potentially lethal of all the skin cancers
Major changes have been made in the surgical procedures and in the therapy for melanoma, the incidence of this skin cancer is still increasing
This paper reports that this change extends into the area around the melanoma which is regarded as normal that is well outside the recommended excision margins
Summary
Melanomas are the most potentially lethal of all the skin cancers. major changes have been made in the surgical procedures and in the therapy for melanoma, the incidence of this skin cancer is still increasing. Changes in the diffraction pattern by alteration of the molecular arrangement or structure are evident in the patterns of pseudo-crystalline materials such as the patterns obtained from keratinous materials, e.g., hair, quills, and feathers, Figure 1a, 1b, 1c and 1d. Changes in these patterns have already been shown to occur if the hair is taken from any mammal with breast or colon cancer [5,6], or horses or humans with. Some of these patients presented for new cancers at the same site three years later
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