THE CONCENTRATION OF ARSENIC IN TISSUES AND THE EXCRETION OF ARSENIC BY EXPERIMENTAL ANIMALS FOLLOWING INTRAVENOUS INJECTION OF MASSIVE DOSES OF MAPHARSEN

Abstract

Article1 June 1941THE CONCENTRATION OF ARSENIC IN TISSUES AND THE EXCRETION OF ARSENIC BY EXPERIMENTAL ANIMALS FOLLOWING INTRAVENOUS INJECTION OF MASSIVE DOSES OF MAPHARSENHAROLD J. MAGNUSON, M.D., B. O. RAULSTON, M.D., F.A.C.P.HAROLD J. MAGNUSON, M.D.Search for more papers by this author, B. O. RAULSTON, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-12-2199 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe use of massive doses of arsenicals, given by the intravenous drip method, in the treatment of syphilis by Hyman, Chargin, Leifer and their co-workers1has stimulated renewed interest and effort directed toward improvement of the generally accepted plans for treatment of this disease. The advantages of reducing the time during which treatment must be continued consecutively and of rapidly stopping the possibility of spreading the disease are self evident. The need of information concerning the distribution of arsenic in the body following injection of large amounts within short periods is conspicuous. The relationship between concentrations of arsenic and its...Bibliography1. HYMANCHARGINLEIFER HTLW: Massive dose arsenotherapy of syphilis by the intravenous drip method, Am. Jr. Syph., Gon. and Ven. Dis., 1939, xxiii, 685-691. HYMAN, H. T., CHARGIN, L., RICE, J. L., and LEIFER, W.: Massive dose chemotherapy of early syphilis by the intravenous drip method, Jr. Am. Med. Assoc., 1939, cxiii, 1208-1214. TZANCK, A., DUPERRAT, and LEWI, S.: Intensive treatment with neoarsphenamine given intravenously at a very slow rate, Bull, et mém. Soc. méd. d. hôp. de Paris, 1938, liv, 268. Google Scholar2. CHANEYMAGNUSON ALHJ: The colorimetric microdetermination of arsenic, Jr. Ind. and Eng. Chem., Anal. Ed., 1940, xii, 691-693. CrossrefGoogle Scholar3. KOLLSYOUMANS ACJB: Quantitative studies with arsphenamine. II. Distribution and excretion after intravenous injection, Bull. Johns Hopkins Hosp., 1923, xxxiv, 181-184. Google Scholar4. UNDERHILLHORN FPM: Concentration of arsenic in blood subsequent to serial administration of neoarsphenamine, Proc. Soc. Exper. Biol. and Med., 1927, xxv, 138-139. CrossrefGoogle Scholar5. KURODA T: Über die Ausscheidung des Arsens durch die Galle, Arch. f. exper. Path. u. Pharmakol., 1927, cxx, 330-340. CrossrefGoogle Scholar6. BULMER FM: Experimental research on distribution and elimination of organic arsenic compounds after intravenous administration, Jr. Pharmacol. and Exper. Therap., 1923, xxi, 301-311. Google Scholar7. FUCHS L: Beitrag zur Verteilung des Arsens im Organismus nach percutaner Resorption therapeutischer Dosen, Deutsch. Ztschr. f. d. ges. gerichtl. Med., 1932, xix, 280-284. Google Scholar8. POPP H: Distribution of arsenic in the bones of the human body, Z. Angew. Chem., 1931, xliv, 658-659. CrossrefGoogle Scholar9. BOOSWERBY WFAB: Arsenic in human tissues and food animals. I. So-called normal arsenic, New Eng. Jr. Med., 1935, ccxiii, 520-524. CrossrefGoogle Scholar10. EAGLE H: Minimal effective concentrations of arsenic and bismuth compounds on Treponema pallidum in vitro in relation to therapeutic dose, Am. Jr. Syph., Gon. and Ven. Dis., 1939, xxiii, 310-318. Google Scholar11. GROSS CR: Interference of pyridine derivatives in arsenic determination, Jr. Ind. and Eng. Chem., Anal. Ed., 1933, v, 58-60. CrossrefGoogle Scholar12. RUDOLFBULMER RDFM: Fate of arsenic after intravenous or intrathecal injection, Am. Jr. Med. Sci., 1923, clxv, 47-53. Google Scholar13. UNDERHILLDIMICK FPA: The distribution of arsenic in the tissues after serial administration of neoarsphenamine, Am. Jr. Physiol., 1928, lxxxiv, 56-60. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Los Angeles, California*Received for publication July 9, 1940.From the Department of Medicine, University of Southern California School of Medicine.†Research Fellow, American College of Physicians.This work aided by grants from Mr. George T. Cook and the John and Mary R. Markle Foundation. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1941Volume 14, Issue 12Page: 2199-2209KeywordsArsenicAttentionExcretionIntravenous injectionsResearch laboratoriesSyphilis ePublished: 1 December 2008 Issue Published: 1 June 1941 PDF downloadLoading ...