Abstract
Plant cyclic nucleotide-gated channels (CNGCs) are tetrameric cation channels which may be activated by the cyclic nucleotides (cNMPs) adenosine 3′,5′-cyclic monophosphate (cAMP) and guanosine 3′,5′-cyclic monophosphate (cGMP). The genome of Arabidopsis thaliana encodes 20 CNGC subunits associated with aspects of development, stress response and immunity. Recently, it has been demonstrated that CNGC subunits form heterotetrameric complexes which behave differently from the homotetramers produced by their constituent subunits. These findings have widespread implications for future signalling research and may help explain how specificity can be achieved by CNGCs that are known to act in disparate pathways. Regulation of complex formation may involve cyclic nucleotide-gated channel-like proteins.
Highlights
Plant cyclic nucleotide-gated channels (CNGCs) are held to be tetrameric cation channels formed by four subunits which may be activated by the cyclic nucleotide monophosphates adenosine 30,50 -cyclic monophosphate and guanosine 30,50 -cyclic monophosphate [1,2,3,4,5,6,7,8,9,10]
It is possible that some of these uncharacterised motifs contribute to CNGC subunit interactions and, if heterotetrameric complexes were confirmed to be widespread amongst CNGCs, these complexes would significantly increase the complexity of CNGC regulation
We examined some of these CNGCL sequences in silico to determine whether they some of theseCNGC–CNGC
Summary
Plant cyclic nucleotide-gated channels (CNGCs) are held to be tetrameric cation channels formed by four subunits which may be activated by the cyclic nucleotide monophosphates (cNMPs) adenosine 30 ,50 -cyclic monophosphate (cAMP) and guanosine 30 ,50 -cyclic monophosphate (cGMP) [1,2,3,4,5,6,7,8,9,10]. The ability of cNMPs to act as signalling molecules in plants has been questioned. CNGCs are integral to plant nutrition, and to calcium (Ca2+ ) signalling in development, abiotic stress and immunity [9,10,12,13,14,15]. Brassica rapa has 30 CNGCs [23]. Complex formation has only been investigated in a few of these cases
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